The APEC Virtual Policy Dialogue on Rare Diseases in Malaysia & the Asia-Pacific was organized by the Rare Diseases Network in partnership with the Ministry of Health Malaysia. It involved a number of speakers from the Ministry of Health together with speakers and panellists from the APEC economies including Phillipines, Singapore, Chinese Taipei, Thailand and Vietnam who shared best practices on rare disease policymaking and planning and the implementation of the APEC Action Plan on Rare Diseases in their respective countries. The speakers from the Ministry of Health were most illuminating on the work of the National Rare Disease Committee and matters under the National Framework for Rare Diseases. Many from the local rare disease community and from the APEC member economies joined in the virtual event.